- Plan for Scheduled Review and Update

The CPG Adaptation Group decided to review this adapted CPG for updates after fiveyears from its publication date (2023/2024) which should be in (2028) after checking for updates in the source guidelines, consultation of expert opinion on the changes needed for updating according to the newest evidence and recommendations published in this area and the clinical audit and feedback from implementation efforts in the Egyptian healthcare setting. The updating process will be guided by the CheckUp (Checklist for the Reporting of Updated Guidelines) Tool.

1.  EPG

2. Supreme Council

3. The funding bodies are official governmental organizations that have provided non-financial logistic and expert clinical and methodological support and have not influenced the formulation of the final evidence-based recommendations. Moreover, this guideline adaptation project was not related to any pharmaceutical, industrial, or any other commercial entity.

All of the GAG members have no conflicts of interest to declare. None of them were associated with or involved in any of the source CPGs that were appraised. Moreover, the competing interests are assessed as part of the AGREE II assessment (Domain 6 Editorial independence).

Future research recommendations for the management of pediatric venous thrombosis in different age groups in the Egyptian context could include:

▪️  Implementation of hemovigilance system at different institutional levels.

▪️  Anticoagulation therapy for specific populations.

These recommendations aim to address specific challenges and characteristics of the Egyptian context, potentially leading to more effective prevention and management strategies for venous thromboembolismin children.

➡️Challenges

▪️  Implementation of international guidelines in resource-limited settings.

▪️ The optimum use of the available resources to fulfill the requirements of the Egyptian population.

Strengthen the evidence base of the next update of this guideline by generating GRADE summary of finding tables, evidence profiles, and EtD frameworks.