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the Management of Skin and Soft Tissue Infections

- Annexes

Table 1 Quality and Significance of the four levels of evidence in GRADE:


Table 2 Factors that determine How to upgrade or downgrade the quality of evidence

Table (3): Surgery of intestinal or genitourinary tract.

Silngle-drug regimens

·  Tetracillin-clavulanate 3.1 g/6h IV

·  Piperacillin-tazobactum 4.375 g/6h or 4.5 g/8h IV

·  Imipenem-cilastatin 500 mg/6h IV

·  Meropenem 1 g/8h IV

·   Ertapenem 1 g/24h IV

Combination regimen

·       Ceftriaxone 1 g/24h + metronidazole 500 mg/8h IV

·  Ciprofloxacin 400 mg IV/12 h or 750 mg po/12 h + metronidazole 500 mg/8h IV

·  Levofloxacin 750 mg IV/24h + metronidazole 500 mg/8h IV

·  Ampicillin-salbactum 4 g/6 h + gentamicin or tobramycin 5 mg/kg/24h IV

Table (4): Surgery of Axilla or Perineum.

·  metronidazole 500 mg/8h IV + Ciprofloxacin 400 mg IV/12 h or 750 mg po/12 h

·   Levofloxacin 750 mg/24h IV po Ceftriaxone 1 g/24h