Monitoring and Antagonism of Neuromuscular Blockade

- Research Gaps

Literature review shows insufficient research data that need further studies for:

·   Studies to confirm that an electromyography train-of-four ratio greater than or equal to 0.9 is associated with improved patient outcomes.

·  The dose of sugammadex required for rocuronium when compared with vecuronium at the same depths of blockade, as sugammadex has a greater affinity for rocuronium than vecuronium.

·  The effects of residual neuromuscular blockade need to be further studied, focusing upon postoperative pulmonary complications and higher-risk surgical patients.

· Direct evidence from randomized trials that compare confirming or not confirming train-of-four ratios before extubation are lacking.