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the Management of Adrenal Lesions

- Annexes

Table 1: Etiology of adrenal tumors presented as adrenal incidentaloma.

Etiology

Prevalence of the different entities among adrenal incidentalomas

Adrenocortical adenoma or macronodular bilateral adrenal hyperplasia

80%-85%

Nonfunctioning

40%-70%

Mild autonomous cortisol secretion

20%-50%

Primary aldosteronism

2%-5%

Overt Cushing's syndrome

1%-4%

Other benign mass:

Myelolipoma

 

3%-6%

Cyst and pseudocyst

1%

Ganglioneuroma

1%

Schwannoma

<1%

Hemorrhage

<1%

Pheochromocytoma

1%-5%

Adrenocortical carcinoma

0.4%-4%

Other malignant mass (mostly adrenal metastases):

3%-7%


Table 2: Quality and Significance of the Four Levels of Evidence in GRADE

Table 3: Factors that Determine How to Upgrade or Downgrade the Quality of Evidence