Critical Limb Threatening Ischemia

The incidence of PAD has increased over the years due to population aging and the global epidemic of diabetes. Some patients progress to CLTI , an advanced stage of PAD. CLTI is associated with increased mortality, risk of amputation, and impaired quality of life. CLTI is a clinical syndrome defined by the presence of PAD in combination with rest pain, gangrene, or a lower limb ulceration >2 weeks duration.