- Isoptin
- Generic Name: Verapamil
- Drug Class: Calcium
Channel Blocker
- Category:
Cardiovascular Diseases
Verapamil is a calcium
channel blocker that reduces calcium influx into the heart muscle and blood
vessels. This action slows conduction through the atrioventricular (AV) node,
decreasing heart rate and vascular resistance. It reduces the force of heart
contractions and relaxes blood vessels, making it useful in treating
hypertension, angina, and arrhythmias.
Common Side Effects:
- Constipation
- Gingival hyperplasia (gum
overgrowth)
- Peripheral edema
- Pulmonary dyspnea
- Rash
- Headache
- Fatigue
- Dizziness
- Nausea
Rare Side Effects:
- Pulmonary edema
- Hypotension
- Hair loss
- Chest pain
- Indigestion
- Muscle spasms
- Elevated liver enzymes
- Development or worsening of heart
failure
- Hypersensitivity reactions,
including erythema multiforme and hepatitis
Contraindications:
- Hypersensitivity to verapamil
- Concurrent use with beta-blockers
- Hypotension (diastolic BP < 90
mmHg)
- Cardiogenic shock
- Ventricular tachycardia
- Significant bradycardia
- Heart failure
Available Forms &
Concentrations:
- Injection Ampoule: 2 mL, 2.5 mg/mL