- Milrinone (Primacor)
- Drug Class: Cardiac
Stimulant
- Category:
Cardiovascular Diseases
- Pharmacological Family:
Phosphodiesterase Inhibitor
Milrinone acts on cardiac
muscle cells and certain blood vessels. It works by inhibiting the enzyme phosphodiesterase,
which typically regulates ion flow into and out of muscle cells. By blocking
this enzyme, the drug increases calcium influx into cardiac muscle cells,
enhancing their contractility. Additionally, it dilates blood vessels, reducing
the heart's workload.
Contraindications:
- Hypersensitivity to any of the
drug’s components
- Concurrent use with inamrinone
Side Effects:
- Headache
- Dizziness
- Skin rash
- Hypotension
- Tremors (especially in the hands)
- Severe allergic reactions
- Breathing difficulties due to
bronchial constriction
- Chest pain (angina)
- Irregular heart rhythms
Available
Forms:
- Injectable Solution: 10 mg/10 mL