- Epinephrine (Adrenaline)
- Drug Class:
Bronchodilator
- Category: Respiratory
Diseases
Epinephrine directly affects
both alpha- and beta-adrenergic receptors in nerve cells, increasing heart rate
and contraction strength, enhancing blood flow to muscles and skeletal tissues,
and relaxing smooth muscles in the airways. It plays a crucial role in treating
severe allergic reactions and can be life-saving in cases of anaphylaxis.
It is also used during cardiac arrest.
Contraindications:
There are no absolute
contraindications for epinephrine in life-threatening situations. However,
caution is advised in cases of:
- Hypersensitivity to
epinephrine or any excipients
- Cardiac arrhythmias
- Angle-closure glaucoma
(when used as eye drops)
Side Effects:
- Central Nervous System:
Anxiety, nervousness, headache, dizziness, weakness
- Gastrointestinal:
Nausea, vomiting
- Cardiovascular System:
- ECG changes
- Arrhythmias
- Palpitations
- Increased risk of myocardial infarction
in coronary artery disease patients
- Potential for fatal ventricular arrhythmias,
especially in those with heart disease
- Repeated injections may cause tissue necrosis
due to vasoconstriction
at the injection site.
Available
Forms:
- Injectable Solution:
- 1 mg/mL (1:1000)
- 0.1 mg/mL (1:10,000)
- Inhalation Solution:
1% (10 mg/mL) as hydrochloride