The diagnosis and management of endometriosis

-  Sufficiently powered, prospective, randomized, and ideally blinded studies to determine whether surgical treatment of superficial peritoneal endometriosis improves short- and long-term outcomes, including pain reduction and quality of life.

-   Evaluation of the impact of surgery for ovarian and deep endometriosis on natural pregnancy rates in patients without a clear indication for ART, accounting for age, endometrioma characteristics, previous surgeries, adenomyosis, and other fertility-related factors.

-   Investigate how the extent of endometriosis affects ART outcomes, to better identify patients who may benefit from ART.

- RCTs to assess whether surgical removal of endometrioma prior to ART improves reproductive outcomes.

- Prospective, long-term studies to explore the association between endometriosis and cancer, using population-based samples, standardized definitions, and comprehensive data collection, while addressing confounders, mediators, and subtype-specific effects by disease and patient characteristics.