Metabolic disorders- hypomagnesemia

Magnesium plays a critical role in neuromuscular stability, enzyme systems and energy metabolism. Magnesium acts as a natural calcium antagonist and inhibitor of acetylcholine (ACh) release at the neuromuscular junction, promoting muscle relaxation

When magnesium decrease, acetylcholine release increases increasing meuromuscular excitability and the nerve cells become hyperactive. Therefore, the animal showed muscle tremors, convulsions, tetany. Death due to respiratory failure.

It is important to mention that unlike calcium, magnesium regulation depends mainly on dietary absorption, not hormonal control. Therefore, diarrhea can induce hypomagnesemia.