Veterinary Anesthesia: - Tranquillizers (Atractic or neuroleptic drugs) | EHC

Types, doses and routs of administration of some tranquilizers in different animals

Route of administration	Dose	Animal	Trade name	Tranquilizers
All routes	1-2 mg/kg b.wt.	Dogs & cats	LargactilÒ, NeurazineÒ	Chlorpromazine Hcl
IV / IM	0.15-0.2 mg /kg b.wt	Horse	LargactilÒ, NeurazineÒ	Chlorpromazine Hcl
IV	2-5 mg / kg b.wt.	Dogs & cats	SparineÒ	Promazine Hcl
IV	1 mg / kg b.wt.	Horse & cattle	SparineÒ	Promazine Hcl
IM	1- 3 mg/kg b.wt.	Dogs & cats	CombelenÒ	Propionyl promazine
IM/IV	0.2 mg/kg b.wt.	Horse	CombelenÒ	Propionyl promazine
IM/IV	1-2 mg/kg b.wt.	Dogs & cats	AcepromazineÒ	Acetyl promazine
IM/IV	0.1-0.2 mg/kg b.wt.	Horse	AcepromazineÒ	Acetyl promazine
IM	0.05-0.15 mg/kg b.wt	Buffaloes	RompunÒ	Xylazine Hcl
IM	0.1-0.3 mg/kg b.wt	Cattle	RompunÒ	Xylazine Hcl
IM	0.1-0.3 mg/kg b.wt	Sheep & goats	RompunÒ	Xylazine Hcl
IV/IM	0.3-1.0 mg/kg b.wt	Dogs	RompunÒ	Xylazine Hcl
IM	0.8-2.0 mg/kg b.wt	Cats	RompunÒ	Xylazine Hcl
IV	1.0-1.1 mg/kg b.wt	horse	RompunÒ	Xylazine Hcl
IV IV IV	5-80 mg/kg b.wt. 10-30 mg/kg b.wt. 40-80 mg/kg b.wt	Horse Cattle Horse	DemosedanÒ DomitorÒ SedivetÒ	Detomedine Medetomidine Romifidine

NB. Antidote: YohimbineÒ or Atipamezole (AnticidanÒ) (according to prescription).

Symptoms of toxic doses:

Hypotension, tremors, dyspnea, convulsions, ataxia and death.

Treatment of toxic doses:

Norepinepherine or phenylephrine

Uses

1- Therapeutic uses;

a- As preanaesthetic sedative

b- To relieve anxiety in hospitalized animals.

c- To restrain refractory animals during examination and radiology.

d- To prevent animals from licking wounds or chewing bandages and splints.

e- As an antiemetic for car sickness or prior to administration of anthelmintics.

f- For treatment in tetanus and colic.

2- In transportation or shipment of large animals.

3- For fattening (calming).

Veterinary Anesthesia