The preparation area for chemotherapy should be
separate from other hospital departments to minimize contamination risk,
as many chemotherapy drugs are fine particles that can easily be inhaled
as aerosol.
If the hospital lacks a chemotherapy preparation unit,
a fixed, suitable area should be designated for preparation.
A cytotoxic drugs spill kit must be available in
chemotherapy rooms to handle any breakage or spillage of chemotherapy
drugs. This kit should include: plastic gloves, a medical coat, safety
glasses, absorbent cloths, cleaning solution, purple plastic bags, and
shoe covers.
Wash hands.
Wear personal protective equipment, including:
Long-sleeve gloves.
Impermeable, long-sleeve protective gown.
Protective glasses, face mask.
Single-use shoes, head cover.
Chemotherapy should be mixed in a Biological Safety
Cabinet.
The ampoule should be broken away from the face and
covered with gauze or cotton.
The diluting solution should be slowly introduced along
the side of the ampoule or vial, ensuring that all powder dissolves before
withdrawal.
Prevent high pressure inside the vial when starting the
mixing and adding the solution.
Air should be purged from the syringe used for
injection on a gauze piece, not into the air.
Purge excess drug from the syringe by removing the
needle and placing a sterile cotton piece to prevent aerosol spread.
Do not refrigerate the prepared drug; it should be used
as soon as possible. The stability period usually lasts 24 hours at
temperatures between 2°C to 8°C.
Return any unused doses or expired drugs to the
pharmacy for proper disposal.
The syringes, tubes, and IV devices used should be of
the Leur-lock type.
Write the patient's name and dose on the solution bag.
Cover the solution before transporting it to the
patient.