Book
THE DIAGNOSIS, TREATMENT, AND PREVENTION OF THROMBOSIS IN PAEDIATRIC AGE GROUPS
- Scope and Purpose
➡️Disease/Condition:
Thrombosis in different pediatric age groups.
➡️Guideline Objectives
To Provide an evidence-based document for the
1. Identification of neonates, infants, children, and adolescents at high risk of thrombosis.
2. Diagnostic approaches in the target population.
3. Management of thrombosis in the target population.
4. Prevention of thrombosis in the target population
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Health / Clinical Question (PIPOH)
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P: Patient (Target Population):
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•Gender: Both genders. • Age group: Neonates, Infants, children & adolescents less than 18 years. • Disease/ Condition: thrombosis (arterial/venous, site, disease categories). • Exclusion criteria: thrombotic microangiopathy, disseminated intravascular coagulopathy, thrombosis due to stasis and/ or blood vessel injury. |
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I: Interventions and Practices Considered / CPG Category:
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Diagnosis: • Venous thrombosis • Arterial thrombosis Treatment • Venous thrombosis • Arterial thrombosis Prevention |
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P: Professionals (Intended / Target Users or Stakeholders) :
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Primary health care physicians at the Ministry of Health, general practitioners, family medicine specialists, pediatricians, hematologists, oncologists, neonatologists, intensive care specialists, surgeons, neurologists, nurses, and medical students. |
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O: Major Outcomes Considered:
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• Primary outcome: - Prevent mortality and morbidity from thrombosis. - Prevent sequelae and disabilities • Secondary outcome: - Family counseling - Prevention of recurrence |
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H: Healthcare Settings:
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Primary, secondary, and tertiary healthcare services mainly outpatient clinics and emergency rooms in governmental, non-governmental and private sectors in Egypt. |
Guidelines 1-5 used the Grading of Recommendations Assessment Development and Evaluation (GRADE) methodology18.Guideline 6 used an early version of GRADE.
Rating Scheme for the Strength of the Evidence/Recommendations:
➡️GRADE ranking of evidence
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High |
Further research is very unlikely to change our confidence in the estimate of effect |
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Moderate |
Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. |
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Low |
Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. |
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Very low |
Any estimate of effect is very uncertain. |
GRADE Ratings for Recommendations For or Against Practice
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Strong |
the panel is confident that the desirable effects of adherence to a recommendation outweigh the unesirable effects |
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conditional |
the panel concludes that the desirable effects of adherence to a recommendation probably outweigh the undesirable effects, but is not confident. |
➡️Good practice statement refers to
Good practice
statements represent recommendations that the Guidelines Development Group
(GDG) feels are important, although they are not adequate for a formal
certainty of evidence rating according to the Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) working group.
