Traumatic Brain edema

Cerebral edema: is an increase in the water content of central nervous system [CNS] cells or interstitium.¹

Refractory intracranial hypertension after traumatic brain injury: recurrent increase of intracranial pressure above 20-22 mmHg for sustained period of time (10-15 min), despite conventional therapies, such as osmotic therapy, cerebral spinal fluid drainage and mild hyperventilation.²