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Prevention and Management of Ovarian Hyperstimulation Syndrome (OHSS)

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"last update: 9 July  2025"                                                                                                           Download Guideline

- Purpose and scope

The purpose of this guideline is to identify quality improvement opportunities in the prevention and management of OHSS and to create explicit and actionable recommendations to implement these opportunities in clinical practice.

Specifically, the goals are to promote the application of preventive interventions that could decrease the incidence of OHSS, especially in high-risk women and to improve early recognition of OHSS symptoms and signs with accurate categorization and prompt management aiming at improving ART health services indicators & avoiding significant physical and psychosocial morbidity that has been associated with OHSS.

This guideline aims to review the literature and provide evidence-based advice to help clinicians prevent, diagnose and manage patients with OHSS.

This guideline provides evidence-based keys to preventing OHSS by identifying the potential risk for the individual patient and planning appropriate strategies to avoid its occurrence during the ART cycle. It also covers the management of established OHSS either by conservative outpatient management in mild to moderate cases or by hospitalization / ICU admission for women with severe or critical OHSS.