Lumpy Skin Disease (LSD) is an acute, infectious viral disease of cattle caused by the Lumpy Skin Disease Virus (LSDV), belonging to the genus Capripoxvirus. Lumpy skin disease is an eruptive, occasionally fatal disease of cattle characterized by nodules on the skin and other parts of the body. Secondary bacterial infection often aggravates the condition. The disease was first identified in Africa, it has spread rapidly across the Middle East, Europe, and Asia. LSD causes significant economic losses due to reduced productivity, hide damage, reproductive losses, and trade restrictions. LSD is emerging viral transboundary disease which can cause acute or sub-acute disease in cattle and rarely in water buffalo. All ages and breeds of cattle are affected, but especially the young and cattle in the peak of lactation.