Lumpy Skin Disease (LSD)

➡️Clinical Diagnosis

The characteristic skin nodules and systemic signs are often sufficient during outbreaks.

➡️Laboratory Diagnosis

·  Polymerase Chain Reaction (PCR): highly specific and sensitive

· Virus Isolation: in cell cultures or embryonated chicken eggs

· Serological Tests: ELISA, virus neutralization test

· Histopathology: necrotizing dermatitis, vasculitis, and inclusion bodies

➡️Differential Diagnosis

· Pseudolumpy skin disease (Bovine Herpesvirus 2): The disease may be confused with the less clinically important pseudo-lumpy skin disease, which is caused by a herpesvirus (bovine herpesvirus 2). These diseases can be similar clinically, although in some parts of the world the herpesvirus lesions seem confined to the teats and udder of cows

· Dermatophilosis

· Bovine papular stomatitis

· Photosensitization

·  Insect bite hypersensitivity