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Prevention of Central Line associated Bloodstream Infections

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"last update: 23 July  2025"                                                                                                            Download Guideline

- Annex



Annex 2.  Differentiating CLABSI and CRBSI (APIC 2014)

Criteria

CLABSI

CRBSI

Purpose of definition

Surveillance

Clinical diagnosis

Device removal required

Usually no

Usually yes

Cultures

Qualitative blood cultures

Blood cultures with differential time to positivity

Catheter tip culture recommended

No

Yes

Major advantage

Convenience, lower cost, readily available in most laboratories

High sensitivity; better positive predictive value

Major disadvantage

Often unable to distinguish a primary and secondary BSI; may overstate the true incidence of primary CLABSI

More complex, less convenient, expensive

Annex 3. Many IV devices are available to deliver medications, fluids and nutrition into patients' bodies, and monitor vital signs. Each carries its own benefits and risks for different patients. Credit: University of Michigan


Examples of central lines: Tunnelled and non-tunnelled central venous catheters, implanted ports, pulmonary artery catheters, dialysis or haemofiltration catheters in a great vessel and peripherally inserted central catheters. An introducer is considered a central line if the tip is situated in a great vessel.

Examples of devices that are not considered to be central lines for the purpose of CLABSI surveillance: Arterial catheters, arteriovenous fistulas, arteriovenous grafts, atrial catheters (also known as transthoracic intra-cardiac catheters, those catheters inserted directly into the right or left atrium via the heart wall), extracorporeal membrane oxygenation (ECMO), femoral arterial catheters, intra-aortic balloon pump (IABP) devices, haemodialysis reliable outflow (HeRO) dialysis catheters, peripheral intravenous cannulae or midline catheters, and ventricular assist devices (VAD). Pacemaker wires and other solid or non‑lumen devices inserted into central blood vessels, or the heart are not considered central lines, because fluids are not infused, pushed, or withdrawn through such devices.