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THE MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION (STEMI)

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"last update: 16 Sept  2025"                                                                                                Download Guideline

- Gap of evidence and future research

Major advances in the management of patients with STEMI have occurred over the last decade yet lack of evidence still prevails in some areas of STEMI spectrum. The following is a list of selected topics that need to be addressed in future research.

(1) Definition and epidemiology

Further research into the underlying characteristics, pathophysiology, and diagnosis of STEMI patients without traditional risk factors.

 (2) Diagnosis

Role of AI in facilitating correct diagnosis of STEMI.

 (3) Pharmacotherapy of STEMI

i. Pragmatic studies on rapid sequencing of disease-modifying drugs for prevention of STEMI.

ii. Specific therapies for coronary ectasia or slow flow coronary artery disease.

iii. Further evidence from prospective RCTs for the treatment of specific STEMI patients, those with ectasia and slow flow.

(4) Devices and interventions

ii. More research on intervention in delayed patients’ presentation.

iii. RCTs on microvascular coronary artery disease.

(5) Self-management

The role of remote monitoring via smart phone applications in STEMI patients.