Book
Diagnosis and management of Guillian Barre Syndrome in children and adolescents
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"last update: 3 Nov 2025" Download Guideline
- Research Gaps
Recommended further research in the field of GBS:
1. In Pathogenesis and Immune Mechanisms
- Better understanding of molecular mimicry between pathogens (e.g., Campylobacter jejuni) and gangliosides.
- Role of complement activation, T-cell subsets, and innate immunity in different GBS variants.
- Exploration of genetic susceptibility (e.g., HLA subtypes, complement-regulatory genes).
- Role of infections and vaccines.
2. Biomarkers and Early Diagnosis
- Development of CSF and blood biomarkers
- Neurofilament light chain (NfL) and anti-ganglioside antibodies as prognostic tools.
- Advanced imaging (e.g., nerve ultrasound, DTI MRI) to detect early inflammation or axonal injury.
3. Treatment options
Trials of novel immunotherapies, such as:
- Complement inhibitors (e.g., eculizumab)
- Anti-GM1 monoclonal antibodies
- T-cell modulation strategies
