Three-Day Sickness (Bovine Ephemeral Fever) in Cattle

After inoculation through insect bites:

Virus enters bloodstream, viremia develops then virus localizes in muscles, joints, and lymphoid tissues. Inflammatory mediators are released, fever and muscle inflammation develop. Hypocalcemia may occur in severe cases.

The disease causes: myositis – polyarthritis - pulmonary edema in severe cases and immunosuppression

Pathogenesis of three-day sickness