Management of Steroid Sensitive Nephrotic Syndrome

AGREE II / CPGs

IPNA clinical practice recommendations (SRNS in children)

JSPN 2014 Nephrotic Syndrome Guideline

KDIGO Glomerular Diseases Guideline

Domain 1 (Scope)

84%

82%

77%

Domain 2 (Stakeholder)

82%

79%

75%

Domain 3 (Rigour)

80%

81%

77%

Domain 4 (Clarity)

79%

83%

75%

Domain 5 (Applicability)

77%

84%

74%

Domain 6 (Independence)

80%

85%

73%

Overall assessment

80%

83%

76%

Recommend for use (Overall assessment)

Yes with modifications

Yes with modifications

Yes with modifications

BASIC INFORMATION

Title/subtitle

1

Identify the report as an adaptation of practice guideline(s), that is include "guideline adaptation", "adapting", "adapted guideline/recommendation(s)", or similar terminology in the title/subtitle.

☒ Yes

☐ No

☐ Unclear

2

Describe the topic/focus/scope of the adapted guideline.

☒ Yes

☐ No

☐ Unclear

Cover/first page

3

Report the respective dates of publication and the literature search of the adapted guideline.

☒ Yes

☐ No

☐ Unclear

4

Describe the developer and country/region of the adapted guideline.

☒ Yes

☐ No

☐ Unclear

Executive summary/abstract

5

Provide a summary of the recommendations contained in the adapted guideline.

☒ Yes

☐ No

☐ Unclear

Abbreviations and acronyms

6

Define key terms and provide a list of abbreviations and acronyms (if applicable).

☒ Yes

☐ No

☐ Unclear

Contact information of the guideline adaptation group

7

Report the contact information of the developer of the adapted guideline.

☒ Yes

☐ No

☐ Unclear

SCOPE

Source guideline(s)

8

Report the name and year of publication of the source guideline(s), provide the citation(s), and whether source authors were contacted.

☒ Yes

☐ No

☐ Unclear

Brief description of the health problem(s)

9

Provide the basic epidemiological information about the problem (including the associated burden), health systems relevant issues, and note any relevant differences compared to the source guideline(s).

☒ Yes

☐ No

☐ Unclear

Aim(s) and specific objectives

10

Describe the aim(s) of the adapted guideline and specific objectives, and note any relevant differences compared to the source guideline(s).

☒ Yes

☐ No

☐ Unclear

Target population(s)

11

Describe the target population(s) and subgroup(s) (if applicable) to which the recommendation(s) is addressed in the adapted guideline, and note any relevant differences compared to the source guideline(s).

☒ Yes

☐ No

☐ Unclear

End-users and settings

12

Describe the intended target users of the adapted guideline, and note any relevant differences compared to the source guideline(s).

☒ Yes

☐ No

☐ Unclear

13

Describe the setting(s) for which the adapted guideline is intended, and note any relevant differences compared to the source guideline(s).

☒ Yes

☐ No

☐ Unclear

RIGOR OF DEVELOPMENT

Guideline adaptation group

14

List all contributors to the guideline adaptation process and describe their selection process and responsibilities.

☒ Yes

☐ No

☐ Unclear

Adaptation framework/methodology

15

Report which framework or methodology was used in the guideline adaptation process.

☒ Yes

☐ No

☐ Unclear

Source guideline(s)

16

Describe how the specific source guideline(s) was(were) selected.

☒ Yes

☐ No

☐ Unclear

Key questions

17

State the key questions of the adapted guideline using a structured format, such as PICO (population, intervention, comparator, and outcome), or another format as appropriate.

☒ Yes

☐ No

☐ Unclear

18

Describe how the key questions were developed/modified, and/or prioritized.

☐ Yes

☒ No

☐ Unclear

Source recommendation(s)

19

Describe how the recommendation(s) from the source guideline(s) was(were) assessed with respect to the evidence considered for the different criteria, the judgements and considerations made by the original panel.

☐ Yes

☒ No

☐ Unclear

Evidence synthesis

20

Indicate whether the adapted recommendation(s) is/are based on existing evidence from the source guideline(s), and/or additional evidence.

☐ Yes

☒ No

☐ Unclear

21

If new research evidence was used, describe how it was identified and assessed.

☐ Yes

☒ No

☐ Unclear

NA

Assessment of the certainty of the body of evidence and strength of recommendation

22

Describe the approach used to assess the certainty/quality of the body/ies of evidence and the strength of recommendations in the adapted guideline and note any differences (if applicable) compared to the source guideline(s).

☐ Yes

☒ No

☐ Unclear

NA

Decision-making processes

23

Describe the processes used by the guideline adaptation group to make decisions, particularly the formulation of recommendations.

☒ Yes

☐ No

☐ Unclear

RECOMMENDATIONS

Recommendations

24

Report recommendations and indicate whether they were adapted, adopted, or de novo.

☒ Yes

☐ No

☐ Unclear

25

Indicate the direction and strength of the recommendations and the certainty/quality of the supporting evidence and note any differences compared to the source recommendations(s) (if applicable).

☒ Yes

☐ No

☐ Unclear

26

Present separate recommendations for important subgroups if the evidence suggests important differences in factors influencing recommendations and note any differences compared to the source recommendations(s) (If applicable).

☒ Yes

☐ No

☐ Unclear

Rationale/explanation for recommendations

27

Describe the criteria/factors that were considered to formulate the recommendations or note any relevant differences compared to the source guideline(s) (if applicable).

☒ Yes

☐ No

☐ Unclear

EXTERNAL REVIEW AND QUALITY ASSURANCE

External review

28

Indicate whether the adapted guideline underwent an independent external review. If yes, describe the process.

☒ Yes

☐ No

☐ Unclear

Organizational approval

29

Indicate whether the adapted guideline obtained organizational approval. If yes, describe the process.

☒ Yes

☐ No

☐ Unclear

SNS  & NEBMC

FUNDING, DECLARATION, AND MANAGEMENT OF INTEREST

Funding source(s) and funder role(s)

30

Report all sources of funding for the adapted guideline and source guideline(s), and the role of the funders.

☒ Yes

☐ No

☐ Unclear

Declaration and management of interests

31

Report all conflicts of interest of the adapted and the source guideline(s) panels, and how they were evaluated and managed.

☒ Yes

☐ No

☐ Unclear

OTHER INFORMATION

Implementation

32

Describe the potential barriers and strategies for implementing the recommendations (if applicable).

☒ Yes

☐ No

☐ Unclear

Update

33

Briefly describe the strategy for updating the adapted guideline (if applicable).

☒ Yes

☐ No

☐ Unclear

Limitations and suggestions for further research

34

Describe the challenges of the adaptation process, the limitations of the evidence, and provide suggestions for future research.

☐ Yes

☒ No

☐ Unclear

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