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steroid‑resistant nephrotic syndrome (SRNS)

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"last update: 17 September 2026"                                                                           Download Guideline

- Abbreviations

ACEI

Angiotensin-converting enzyme inhibitor

ACR

American College of Rheumatology of SLE

Adolopment

Adoption-Adaptation-Development

AGREE II

Appraisal of Guidelines for Research and Evaluation Instrument

AGBM

Anti-glomerular basement membrane antibodies

AHUS

Atypical hemolytic uremic syndrome

AKI

Acute kidney injury

ANCA

Antineutrophil cytoplasmic antibodies

ANCAV

ANCA vasculitis

APS

Anti-phospholipid syndrome

ARBs.

Angiotensin receptor blockers

ASOT

Antistreptolysin O titer

AZA

Azathioprine

BMD

Bone mineral disease

C3/DDD

Complement 3/dense deposit disease

C3G

Complement 3 glomerulopathy

C3GN

Complement 3 glomerulonephritis

CR

Complete remission

CKD

Chronic kidney disease

CNI

Calcineurin

CPD

Chronic peritoneal dialysis

CPG

Clinical Practice Guideline

CRF

Chronic renal failure

CS

Corticosteroid

CSF

Cerebrospinal fluid

CYC

Cyclophosphamide

CYS R

Cyclosporin resistant

CVD

Cardiovascular disease

DDD

Dense deposit disease

DHS

Demographic and Health Survey

DMS

Diffuse mesangial sclerosis

EM

Electron microscopy

EMA

European Medicines Agency

EPG

Egyptian Pediatrics Clinical Practice Guidelines Committee

EPG CPG

EPG Clinical Practice Guideline

ERG

External Review Group

ESKD

End-stage kidney disease

ESRD

End-stage renal disease

EULAR

European League Against Rheumatism/American College

FR

Frequent relapse

FSGS

focal and segmental glomerulosclerosis

GAG

Guideline Adaptation Group

GDG

Guideline Development Group

GFR

Glomerular filtration rate

GIT

Gastroenteritis

GPS

Good Practice Statement

GRADE

Grading of Recommendations Assessment, Development and Evaluation

GT

Genetic tests

Glucocorticoids

Steroids

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HIV

Human immunodeficiency virus

IF

Immunofluorescopy

IFTA

Interstitial fibrosis tubular atrophy

IgAV

IgA vasculitis

IgAN

IgA nephropathy

INR

International formalized ratio

IPNA

International Pediatric Nephrology Association

ISKDC

International Study Kidney Disease in Children

ISN/RPS

International Society of Nephrology/Renal Pathology Society

I.V

Intravenous

IV CYC

Intravenous cyclophosphamide

IV MP

Intravenous methyl prednisone

KDIGO

Kidney Disease International Global outcome

LM

Light microscopy

LN

Lupus nephritis

MCD

Minimal change disease

MCNS

Minimal change nephrotic syndrome

MDR

Multidrug resistant

mg/kg

Milligram of medication per kilogram of body weight

MMF

Mycophenolate mofetil

MN

Membranous nephropathy

MP

Methylprednisolone

MP

Membranoproliferative

NCGL

National Clinical Guideline

NGS

Next-generation sequencing

NS

Nephrotic syndrome

NS-GAG

Nephrotic Syndrome Guideline Adaptation Group

PICO

population, intervention, comparison, and outcomes

PIPOH

 

Patient population, intervention, professionals, outcomes, and healthcare context

PDN

Prednisone

PE

Plasma exchange

PLA2R

Phospholipase A2 receptor antibodies

  PNC

Pediatric nephrology center

  PP

Practice point

  PR

Partial remission

  PSGN

Post streptococcal glomerulonephritis

  RASI

Renin angiotensin system inhibitor

RIGHT

A Reporting Tool for Practice Guidelines in Health Care

RPGN

Rapidly progressive glomerulonephritis

SCr

Serum creatinine

SD

Steroid dependent

SLE

Systemic lupus erythematosus

SLEDAI

Diffuse activity index for lupus patients

SRNS

Steroid resistant nephrotic syndrome

SSNS

steroid-sensitive nephrotic syndrome

TMA

Thrombotic microangiopathy

TX

Transplantation

TTP

Thrombotic thrombocytopenic purpura

UPCR

Urine protein creatinine ratio

VZIG

Varicella-zoster immune globulin

WES

Whole exon sequencing

WGS

Whole genome sequencing