Localized Colon Cancer

Annex 1.

Annex 2.

DOSES OF ADJUVANT CHEMOTHERAPY REGIMENS

-  mFOLFOX 6

Oxaliplatin 85 mg/m2 IV, day 1a Leucovorin 400 mg/m2 IV, day 1b

5-FU 400 mg/m2 IV bolus on day 1, followed by 1200 mg/m2/day x 2 days (total 2400 mg/m2 over 46–48 hours) continuous infusion.

Repeat every 2 weeks.1,2,3

-  Capecitabine

Capecitabine 1000–1250c mg/m2 PO twice daily for 14 days every 3 weeks

-  CAPEOX

Oxaliplatin 130 mg/m2 IVa day 1

Capecitabine 1000c mg/m2 PO twice daily for 14 days every 3 weeks

-  5-FU/leucovorin

- Leucovorin 500 mg/m2 given as a 2-hour infusion and repeated weekly x 6. 5-FU 500 mg/m2 given bolus 1 hour after the start of leucovorin and repeated 6 x weekly. Every 8 weeks for 4 cycles.

- Simplified biweekly infusional 5-FU/leucovorin (sLV5FU2)

Leucovorin 400b mg/m2 IV day 1, followed by 5-FU bolus 400 mg/m2, followed by 1200 mg/m2/day x 2 days (total 2400 mg/m2 over 46–48 hours) continuous infusion. Repeat every 2 weeks.

Annex 3.

l  When determining if adjuvant therapy should be administered for stage II, the following should be taken into consideration:

- Number of lymph nodes analyzed after surgery (<12)

- Poor prognostic features (eg, poorly differentiated histology [exclusive of those that are MSI-H]; lymphatic/vascular invasion; bowel obstruction; PNI; localized perforation; close, indeterminate, or positive margins; or high tumor budding)

Annex 4. Recommendations from the IDEA study for adjuvant treatment of colon cancer (32).

➡️Diagnostic work-up for localized colon cancer